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Check Closely (1)phenobarbital will decrease the level or outcome of fentanyl transmucosal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with CYP3A4 inducers may lead to your lessen in fentanyl plasma concentrations, lack of efficacy or, potentially, development of a withdrawa